FIRST PROFESSIONAL
PHARMACEUTICAL CHEMISTRY-I (ORGANIC)
- BASIC CONCEPTS:
i)
Conjugation,
iii)
Steric effect,
viii) Effect of structure on
reactivity of compounds.
ix) Tautamerism of carbonylcompounds.
- NUCLEOPHILIC AND ELECTROPHILIC SUBSTITUTION REACTION IN ALIPHATICAND AROMATIC SYSTEMS.
- ORIENTATION IN ELECTROPHILIC SUBSTITUTION REACTIONS ON BENZENERING.
- ORGANIC REACTIONS:
iii)
Grignard's reaction
iv)
Metal hydride reductionand Wolf Krishner reduction
vi)
Perkin reaction
vii)Cannizzaro reaction.
- CARBONIUM ION REARRANGEMENTS:
i)
Pinacol-pinacolone
ii)
Wagner-Meerwein
iii) Wolf, Hofmann and Beckmann rearrangements.
- CARBANIONS:
i)
Condensation reaction
ii)
Aldol condensation
iii) Favorskii
rearrangement
iv) Witting reaction
- STEREOCHEMISTRY:
i)
Stereoisomerism
ii)
Optical isomerism
iii)
Molecules with more than
one chiral center.
iv)
Geometrical isomerism
v)
Resolution of racemic mixture.
vi) Conformational analysis.
- FREE RADICALS: Introduction, structure and stability, preparation and properties.
- GENERAL METHODS OF PREPARATIONS, PROPERTIES, IDENTIFICATION TEST AND PHARMACEUTICAL APPLICATIONS OF THE FOLLOWING CLASSES AND THEIR ANALOGUES:
i)
Alcohols
ii)
Phenols
iii)
Ethers
iv)
Aldehydes
v)
Ketones
vi)
Acids
vii)Esters
viii)
Amines
ix) Aniline.
- PREPARATION AND PROPERTIES OF MEDICINALLY IMPORTANT HETEROCYCLIC COMPOUNDS
i)
Pyrrol
ii)
Furan
iii)
Thiophene
iv)
Pyridine
v)
Pyrimidine
vi) Pyrazine.
- PREPARATION AND PROPERTIES OF HETEROCYCLIC COMPOUNDS in which benzo-ring is fused with five and six membered ring containing one heteroatom;
I.
Indole,
II.
Quinoline and
III.
Isoquinoline.
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