PHARMACEUTICS –VII (BIOPHARMACEUTICS)
DEFINITIONS AND
TERMINOLOGY:
Biopharmaceutics,
Generic
Equivalence,
Bioavailability,
Bioequivalence,
Drug
Disposition,
Therapeutics,
Pharmacokinetics,
Biotransformation
and
Therapeutic
Equivalents.
GASTRO-INTESTINAL ABSORPTION
AND PHYSICO-CHEMICAL CONSIDERATIONS:
Forces
which help in transmembrane movements,
pH
Partition Theory,
Lipid
Solubility
Factors
affecting Bioavailability.
BIOAVAILABILITY STUDIES:
Purpose,
Relative
and Absolute Bioavailability, and
Determination
of Bioavailability.
FACTORS AFFECTING
DISSOLUTION IN RESPECT OF BIOAVAILABILITY:
Methods
of in-vitro and in-vivo determination of rate of dissolution.
MULTIPLE DOSAGE REGEMIN.
INTRAVENOUS INFUSIONS.
BIOPHARMACEUTICAL AND
PHARMACOKINETIC ASPECTS IN DEVELOPING A DOSAGE FORM.
INTRODUCTION TO
PHARMACOKINETICS:
Determination
through plasma drug level studies.
Application
of pharmacokinetics in clinical situations.
CONCEPT OF COMPARTMENT(S)
MODELS:
One
compartment open model.
Two
compartment open model.
Three compartment
open model
Non-compartmental
method of analysis.
BIOLOGICAL HALF-LIFE AND
VOLUME OF DISTRIBUTION:
Concept
and Methods of Determination.
DRUG CLEARANCE:
Mechanism,
determination
and relationship of clearance with half-life.
ELIMINATION OF DRUGS:
Hepatic
Elimination:
Percent of Drug Metabolized,
Drug Biotransformation reactions,
Phase-I reactions
Phase-II reactions,
First pass effect,
Hepatic clearance of protein
bound drugs and
Biliary excretion of drugs.
Renal Excretion of Drugs:
Renal clearance,
Tubular Secretion and
Tubular Reabsorption.
Elimination of Drugs through other organs:
Pulmonary excretion,
Salivary excretion,
Mammary excretion,
Skin excretion and
Genital excretion.
PROTEIN BINDING:
Determination
of plasma protein binding and
Clinical
significance of drug-protein binding.
APPLICATIONS OF
PHARMACOKINETICS AND BIOAVAILABILITY IN CLINICAL SITUATIONS.
APPLICATIONS OF PHARMACOKIENTICS
IN DISEASE STATES.
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