PHARMACEUTICAL MICROBIOLOGY

PHARMACEUTICAL MICROBIOLOGY

1.   GENERAL MICROBIOLOGY:

a.   Historical Introduction,

b.   Scope of Microbiology with special reference to Pharmaceutical Sciences.

c.   Nomenclature and classification of Micro-organisms.

2.   ORGANISMS:

a.   The Bacteria: General and cellular Morphology, structure and function.

b.   Classification of Bacteria.

c.   Growth curve,

d.   Growth factors and

e.   Growth characteristics.

f.     Nutrition, Requirements and Nutrition factors affecting growth.

g.   Culture Media,

h.   Bacterial cultures and staining Methods.

i.     The Viruses: Introduction, Classification (and detail of at least one species from every group), cultivation, and replication.

3.   THE FUNGI/YEAST/MOLDS.

4.   THE PROTOZOA.

5.   The NORMAL FLORA:

Microbiology of air, water and soil (general introduction and normal inhibitants of air, water, and soil).

6.   INDUSTRIAL MICROBIOLOGY:

a.   Introduction to Sterilization/ Disinfection.

b.   Fermentation.

c.   Pharmaceutical products produced by fermentation process:

d.   Penicillins,

e.   Cepalosporins,

f.     Gentamycin,

g.   Erythromycin,

h.   Tetracyclines,

i.     Rifamycin,

j.     Griseofulvin.

7.   IMMUNOLOGY:

a.   Introduction, Types of Immunity:

b.   Specific and nonspecific Immunity

c.   Cellular basis of Immune response.

d.   Immunity,

e.   Autoimmunity,

f.     Tolerance.

g.   Antigen.

h.   Anti-bodies.

i.     Antigen — Anti-body reactions and their clinical and diagnostic applications. Hypersensitivity and allergy.

j.     Drug allergy mechanism.

k.    Vaccination: Introduction and aims.

l.     Types of Vaccines.

m. Current vaccine practices.

8.   FACTORY AND HOSPITAL HYGIENE AND GOOD MANUFACTURING PRACTICE:

a.   Introduction, Control of Microbial contamination during manufacture,

b.   Manufacture of Sterile products,

c.   A Guide to Current Good Pharmaceutical Manufacturing Practices.