PHARAMCEUTICAL CHEMISTRY-III (MEDICINAL CHEMISTRY)

FINAL PROFESSIONAL

PHARAMCEUTICAL CHEMISTRY-III (MEDICINAL CHEMISTRY)

Note: The topics will be taught with special reference to their

Pharmaceutical Applications.

INTRODUCTION TO MEDICINAL CHEMISTRY:

Chemical constitution and biological activity:

Receptor,

Theory,

Structure Activity Relationships (SAR)

Drug Metabolism

CLASSIFICATION OF SYNTHETIC DRUGS:

Drug Design and recent approaches to the synthesis of drugs (a brief concept of methods and reactions of synthesis of various drugs).

GENERAL PROPERTIES, CHEMISTRY BIOLOGICAL ACTION,

STRUCTURE ACTIVITY RELATIONSHIP AND THERAPEUTIC

APPLICATIONS OF THE FOLLOWING:

Alicyclic Compounds:

Cyclopropane,

Terpenes,

Citral,

Pinene,

Camphor,

Menthol,

Carotenes.

Alkaloids:

Atropine,

Morphine

Codeine,

Thebaine,

Ergotamine,

Reserpine,

Ephedrine.

Vitamins:

Water Soluble Vitamins:

Vitamin B1,

Vitamin B2,

Vitamin B6,

Vitamin B12,

Folic acid,

Nicotinic acid,

Biotin,

Pantothenic acid

Ascorbic acid

Fat Soluble Vitamins:

Vitamin A,

Vitamin D,

Vitamin E,

Vitamin K.

Hormones:

Steroidal Hormones:

Testosterone,

Progesterone,

Estrogen,

Aldosteron

Cortisol,

Proteinous Hormones:

Insulin,

Glucagon,

Oxytocin

Vassopressin.

Anti-neoplastic Agents:

Tamoxifen,

Fluorouracil,

Mercapturine,

Methotrexate

Vincristine.

Sedatives and Hypnotics:

Benzodiazepines,

Barbiturates,

Paraldehyde,

Glutethimide,

Chloral hydrate,

Alcohols.

Anaesthetics:

Local anaesthetics:

Procaine,

Lignocaine,

Eucaine,

Cocaine

Benzocaine,

General anaesthetics:

Cyclopropane,

Halothane,

Nitrous oxide,

Chloroform,

Thiopental Sodium,

Ketamine,

Methohexital,

Thioamylal Sodium,

Fantanyl Citrate,

Tribromo ethanol.

Analgesics and Antipyretics:

Paracetamol,

Salicylic acid analogues,

Quinolines derivatives,

Pyrazolone and Pyrazolodiones,

Narylanthranilic acids,

Aryl and heteroaryl acetic acid derivatives.

Antiseptics:

Phenols and related compounds,

Halogens and Halogen compounds,

Aromatic acid and esters,

Dyes,

Nitrofuran derivatives,

Formaldehyde and its derivatives,

Mercurochrome

Thiomersal.

Sulphonamides:

Prontosil,

sulphanilamide,

Sulphapyridine,

sulphadimidine,

Sulfamethoxazole,

Sulfadiazine

Sulfafurazole.

Antimalarials:

4-Aminoquinolines,

8-Aminoquinolines,

9-Amino acridines,

Biguanides,

Pyrimidine analogues,

Mefloquine

Cinchoha alkaloids.

Anthelmintics:

Phenols and related compounds,

Piperazine derivatives,

Thiabendazole,

Mebendazole

Pyrantal.

Diuretics:

Mercaptomerin,

Meralluride,

Thiazides,

Sprironolac-tone,

Theophylline,

Furosemide,

Acetazolamiode,

Ethacrynic acid

Triameterene.

Antitubercular Drugs:

Ethambutol,

Isonicotinic acid,

Hydrazid,

Rifampacin,

Thioguanine,

Pyrazinamide,

cycloserine,

Ethunamide,

Cytarabine,

5-Flourouracil

Dacarbazine.

Antiviral Drugs:

Acyclovir,

Tromantadine Hydrochloride

Ribavirin.

Immunosuppressant Agents:

Azathioprine

Cyclosporin.

ANTIBIOTICS:

Penicillins,

Cephalosporins,

Streptomycin,

Chloramphenicol,

Tetracyclines,

Kanamycin

Erythromycin.

OCCURANCE, PROPERTIES, PREPARATION AND APPLICATION

OF OFFICIAL INORGANIC COMPOUNDS:

Aluminium Hydroxide,

Ammonium Chloride,

Sodium Carbonate,

Magnesium Carbonate,

Lithium Carbonate,

Sodium Nitrite,

Calcium Gluconate,

Antimony Gluconate,

Ferrous Fumarate,

Ferrous Sulfate

Silver Nitrate.