Granulation, Dry Granulation and Direct Compression

 

Granulation, Dry Granulation and Direct Compression

Wet granulation	Dry granulation	Direct compression
Milling and mixing of drugs and excipients	Milling and mixing of drugs and excipients	Milling and mixing of drugs and excipients
Preparation of binder solution	Compression into slugs or roll compaction	Compression of tablet
Wet massing by addition of binder solution or granulating solvent	Milling and screening of slugs and compacted powder
Screening of wet mass	Mixing with lubricant and disintegrant
Drying of the wet granules	Compression of tablet
Screening of dry granules
Blending with lubricant and disintegrant to produce “running powder”
Compression of tablet