Fractional Liberation

 

Fractional Liberation

Fractional Liberation

—  Fractional liberation  is a technique in which the compounds or chemicals are separated from a mixture by the formation of precipitate.

—  The separation is carried out by changing the compounds the compounds into their salt form.

—  Purification of cinnamon alkaloid is usually carried out using this technique.

—  When a mixture of alkaloid salt is treated with an alkali it 1^st form a weak base in its free state which is followed by base liberation.

—  This liberation process occur in ascending order of basicity.

—  By shaking the mixture with organic solvent after every addition a series of bases fractions are obtained.

—  Similarly for the liberation of organic acid present in water immiscible solvent same pattern is used.

—  In this case a mixture of acid salt is will be treated with mineral acid to fractionally liberate acids.

Presented by

Muhammad Atif

PhD Scholar Pharmaceutical Sciences

Abdul Wali Khan University Mardan, Pakistan